A novel approach to a complex disease

Neurotrophic hepatocyte growth factor (HGF) enhancement may help to:

Address the multifactorial nature of Alzheimer’s disease (AD)¹

Numerous factors, including intra- and extracellular protein pathologies and immune-mediated inflammation, contribute to AD-associated neurodegeneration²

Protect and repair neuronal networks³

Leveraging intrinsic protection and repair systems, such as neurotrophic HGF, may help to reestablish connections between neurons that are lost in neurodegenerative disease, potentially improving neuronal network function and communication

Improve learning and memory^3,4

Promotion and recovery of neuronal connectivity may contribute to increased cognition and function

Neurotrophic HGF is a critical factor in brain health, offering the potential to improve learning and memory in people with AD³

Learn more about Athira and the science of neurotrophic HGF at athira.com

References:

1. Desole C, Gallo S, Vitacolona A, et al. HGF and MET: from brain development to neurological disorders. Front Cell Dev Bio. 2021. doi:3389/fcell.2021.683609 2. Takeuchi D, Sato N, Shimamura M, et al. Alleviation of Ab-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model. Gene Ther. 2008;15(8):561-571. 3. Wei J, Ma X, Nehme A, Cui Y, Zhang L, Qiu S. Reduced HGF/MET signaling may contribute to the synaptic pathology in an Alzheimer’s Disease mouse model. Front Aging Neurosci. 2022. doi:10.3389/fnagi.2022.954266 4. Johnston JL, Reda SM, Setti SE, et al. Fosgonimeton, a novel positive modulator of the HGF/MET system, promotes neurotrophic and procognitive effects in models of dementia. Neurotherapeutics. 2023;20(2):431-451.